Approximately 25% of strains related to back fatigue and overuse in the work setting result in loss of workdays and productivity. 1 Research indicates the vast majority of physical pain is related to inflammation. Inflammation occurs as a response to pathogens and often when it occurs swelling, heat, pain and redness are experienced. 2 Studies suggest inflammation occurs through two metabolic pathways that result in the production of various compounds known as eicosanoids. 3 Research suggests if inflammation can be reduced, the frequency or degree of pain experienced may be greatly diminished.
Roex® Flamatrol Pain Formula provides a blend of ingredients including Meriva Curcumin, MSM, Devil’s Claw, Frankincense, White Willow bark extract, Myrrh and Turmeric with a recommended dose of 2-650mg capsules twice daily that reduce pain symptoms in a natural, non-habit forming manner that does not raise the level of risk associated with many synthetic pain relief products that can be extremely harsh on the body and induce negative side effects.
Meriva® Curcumin & Turmeric (Curcuma Longa)
Meriva Curcumin is a specialized bioavailable curcumin-phosphatidylcholine complex that aids in pain management. Curcumin, the yellow pigment in turmeric, a hydrophobic polyphenol, has been extensively used to mediate inflammation. Turmeric has an extensive history of use in moderating inflammation and exhibits potent antioxidant properties. 4 Its chief chemical property curcumin, embodies 90% of the entire curcuminoid matter. 5 Research indicates curcumin provides anti-inflammatory benefits by, “inhibiting pro-inflammatory enzymes such as COX and lipoxygenases, inflammatory transcription factors, signal transducer and activator of transcription 3, as well as their genomic expression.” 6 While the benefits of unformulated curcumin have been examined, the major hindrance to curcumin lies in that it displays poor stability during initial consumption phases. Research suggests once curcumin is able to enter the plasma it is then highly stable and permeable. 7 Meriva, a phytosome complexing curcumin with phosphatidylcholine was created to provide hydrolytic stabilization, and increase oral absorption rates greater than 29 times of unformulated curcumin.* 8
Myriad clinical research has been conducted providing efficacy of Meriva as a tool for management of inflammation and pain. 50 participants over 3 months experiencing knee joint inflammatory related pain were given the standard “best available treatment” while the treatment group also received 1g/day of Meriva. Use resulted in a 58% decrease in WOMAC scores including walking performance score increases from 76 at baseline pre-trial to 332 meters post-trial. Levels of C-reactive protein, a marker for inflammation, also decreased greatly as much as 157 mg/L decrease. Users also showed a 63% in painkiller use decrease and 38% decrease in experienced gastrointestinal complications after administration of Meriva compared to controls. Results indicated the complex not only relieved pain but also increased mobility in participants using Meriva. The major curcuminoid in Meriva is demethoxycurcumin, an even more potent analogue than curcumin.4,9,10,11
An extension of the previous study was completed, 8 months in length with 100 participants to examine the long-term benefits of Meriva. Results found reduction in WOMAC scores measuring pain, stiffness and physical function limitations from baseline 80.6 to 33.3, improved Karnofsky Performance scores, as well as inflammation markers, which all showed reductions from Meriva use.*4
Undenatured type II collagen is derived from chicken sternum cartilage, including epitopes, and research has found it is highly efficacious in the promotion of joint health and the reduction of joint pain and discomfort symptoms with extended lasting benefits. UC−ΙΙ works by prompting the deactivation of the inflammation, which is the leading cause of pain. It prevents the breakdown of joint cartilage, in a quick acting manner allowing the body to recover from the inflammation and resume normal joint functioning. Clinical studies found that administration of UC−II was more than twice as effective that use of high quality glucosamine and chondroitin, including a 52-subject, 90-day study with 40 mg of UC−II compared to 1,500mg of glucosamine and 1,200mg of chondroitin in the decrease of knee pain. The study also found improvements in various scores of scales related to measurement of joint pain and functioning, such as the WOMAC index, VAS score, and Lesquesne index. 12 A pilot study including 5 women found that UC−II use for 42 days resulted in reduced morning stiffness and significantly reduced pain. 13 UC−II is well tolerated and GRAS.* 14, 15
Additional Ingredients in Flamatrol®
White Willow Bark Extract (Salix alba) - White Willow Bark extract has long been used as a mediator of pain and is the original source from which aspirin was derived.*
MSM - Methylsulfonylmethane (MSM), a naturally occurring sulfur compound exhibits anti-inflammatory properties and provides antioxidant support that may be able to stabilize oxidative stress that physical activity may induce.*
Devil’s Claw (Harpagophytum procumbens) – Devil’s Claw is believed to have anti-inflammatory properties associated with reduction in both musculoskeletal and joint related pain.*
Frankincense (Boswellia serrata) & Myrrh (Commiphora mukul) - Frankincense and myrrh, gum resins exhibiting anti-inflammatory benefits, have an extensive history of use in Ayurvedic medicine.*